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Researches of Pueraria Mirifica

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The Pueraria family with special interest in Pueraria Mirifica

Author: Anthony C. Dweck. FLS FRSC FRSH
Lab : N/A

The genus Pueraria is not abundant in the literature, although there seems to be some correlation between the different species that is encouraging to the phytochemist.

Published: N/A

Long-Term Treatment Effects of Pueraria Mirifica Phytoestrogens on Parathyroid Hormone and Calcium Levels in Aged Menopausal Cynomolgus Monkeys

Authors: Htaitip Trisomboon, Suchinda Malaivijitnond, Juri Suzaki, Yuzuru Hamada, Gen Watanabe and Kazuyoshi Taya
1. Biological Science Ph.D. Program, Faculty of Science, Chulalongkorn University, Bangkok 10330
2.Primate Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
3. Primate Research Institute, Kyoto University, Inuyama, Aichi 484-8506
4. Laboratory of Veterinary Physiology, Tokyo University of Agriculture and TEchnology, Tokyo 183-8509
5. Department of Basic Veterinary Science, The United Graduate School of Verinary Science, Gifu University, Gifu 501-11093, Japan

To determine the effect of Pueraria Mirifica (PM) on serum parathyroid hormone (PTH) and calcium elvels on aged menopausal monkeys (Macaca fascicularis), subjects were treated with 10, 100, or 1,000 mg/day of PM. Blood samples were collected every 5 days for 30, 90 and 60 days during pre-treatment, treatment, and post-treatment periods, respectively. Sera were assayed for PTH, estradiol, and calcium levels. PM-1,000 had the strongest effect on the decrease in PTH (0.001<P≤0.05) and calcium levels (0.001<P≤0.03) during the treatment period. PTH levels remained low for the first 15 days of the post-treatment period (0.01≤P≤0.05). PM-10 induced a significant decrease in PTH level on day (P=0.02) during the treatment period and significant decrease in calcium level on day 75 (P<0.01). There were no changes in serum PTH and calcium levels throughout the study period in the PM-100 group. Estradiol levels decreased significantly during the treatment period in all treatment groups. The results suggest that long-term treatment with 1,000mg/day of PM decreases serum PTH and calcium levels in aged menopausal monkeys, indicating that PM ameliorates bone loss caused by estrogen deficiency.

Published: August 17, 2004
Key words: Pueraria Mirifica, Phytoestrogen, PTH, Calcium, Aged menopausal monkey
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