Researches of Butea Superba
Effects of Butea Superba on reproductive system of rats
Authors : Aranya Manosroi, Kanokporn Sanphet, Suda Saowakon, Salika Aritajat, Jiradej Manosroi
1. Natural Products for Thai Traditional Medicine Research Unit, Pharmaceutical-Cosmetic Raw Materials and Natural Products Research and Development Center (PCRNC), Institude for Science and TEchnology Research and Development, chiang Mai University
2. Faculty of Pharmacy, Chiang Mai University
3. Reproductive Physiology Research Unit, Department of Biology, Faculty of Sciences, Chiang Mai University
The effects of Butea Superba on the reproductive system in male Wistar rats were investigated. The animals were fed daily with the powdered crude drug suspended in distilled water by a gastric tube at the dose of 2, 25, 250 and 1250 mg/kg body weight for 8 weeks. Rats fed with 1 ml of distilled water were used as a negative control. The weights of all vital organs in all treated groups were not different from the control. The percentage weight ratios of body weights of semial vesicles and prostate glands were not different from the control, except that the testis of the group fed with 1250 mg/kg was significantly different from the control and the other treated groups. In addition, the sperm counts in this group showed about 16% more than the control group. Hematology as well as the liver and kidney function of all treated groups showed no difference from the control. Butea Superba, drug at 250 mg/kg which was 100 times more than the Thai FDA recommended dose for humans appeared to be safe in rats. The crude drug has demonstrated an increase tendency on testis weight and sperm counts in rat. The information from the present study can be used to explain the Thai folklore application of this plant in Thailand.
Butea Superba Secret Mens Supports Healthy Cardiovascular System
For us, the cardiovasular system of man is as follows: Oxygenated blood is pumped by the left ventricle of the heart to the aorta. Conclusion The cardiovascular system of animals consists of the heart and blood vessels. The blood that is returned to the heart is then recycled through the cardiovascular system.
Effects of Long-term Treatment of Butea Superba on Sperm Motility and Concentration
Author: Rattima Jeenapongsa
1. Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
2. Faculty of Science, Mae Fah Luang University, Chiangrai 57100, Thailand.
Butea Superba has been used to enhance sexual performanace in men with unknown long-term effects on spermatozoa. This study aimed to investigate effects of chronic treatment of Butea Superba on sperm motility and concentration in rats and mice in correlation with testicular damage. Adult male rats and mice were orally administered distilled water or Butea Superba alcoholic extract (0.01, 0.1 or 1.0 mg/kg BW/day) for 6 months. At the end of the treatment the animals were sacrificed and the spermatozoa recovered from the distal cauda epididymis were analyzed fro sperm concentration and motility in vitro . The testes were processed for histological examination. The results show that long-term treatment with Butea Superba extract significantly increased the sperm concentration and delayed the decreased motility with time. None of signs of sperms anomalies and testicular damanges were observed. This suggests that chronic use of Butea Superba increases the number of sperm, prolongs sperm motility in vitro while produces no changes on sperm morphology. Therefore, chronic use of Butea Superba alcoholic extract may be useful in fertilization.
Hepatoprotective activity of Butea Superba against carbon tetrachloride induced hepatic damange in rodents
Authors: B. K. Manjunatha., K. L. Mankani., S. M. Vidya., V. Krishna and Y. N. Manohara
1. Department of Biotechnology, The Oxford College of Engineering, Bommanahalli, Hosur road, Bangalore-68
2. Department of Biotechnology, Nitte College of Engineering, Nitte
3. Department of Pharmacology, National College of Pharmacy Shimoga- 577 201, Karnataka
4. Department of Biotechnology Kuvempu University, Shankaraghatta- 577 451, Kanataka, India
Ethanolic extract of stem bark of Butea Superba was investigated for hepatoprotective activity against carbon tetrachloride induced liver damage. VArious biochemical parameters were studied to evaluate the hepatoprotective activity of crude etract. In serum, total bilirubin, total protein, aspartate transaminase, alanine transaminase and alkaline phosphatases were determined to assess the effect of the extract on the CCI induced hepatic dmanage. The study was also supported by histopathology of liver sections. Results of this study revealed that the serum markers in the animals treated with CCI recorded elevated concentration indicating severe hepatic damage by CCI. Where as the blood samples from the animals treated with ethanol extract of stem bark showed significant reduction in the serum markers indicating the effect of the plant extract in restoring the normal functional ability of the hepatocytes. Among the two doses of the extract tested, the hepatoprotective activity was more pronounced at the dose of 100 mg/kg. The present study reveals that the ethanol stem bark extract of Butea Superba could afford a significant protection against CCI induced hepatocellular injury.