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Researches of Pueraria Mirifica

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Effects of Pueraria mirifica on Teat and Reproductive Organs of Immature Female Pigs

Author: Phd. Yutana Samitrasiri

Immature female pigs 1.5 month-old were fed with dried Pueraria mirifica tuber powder (PM), which possessed estrogen-like activity, everyday at the dosage of 25, 50 g/day for 8 consecutive weeks compared with the control group (6 piglets/group). It was found that PM could induce the teat and vaginal development within the first week after PM treatment. PM not only could increase the number of teats and their development but also induce the shedding of hair occur as well as regrowth, with the new hair longer and shinier; the flaking of epidermis especially in the head and body region, the basic pH of; vaginal mucus. After 8 weeks of treatment, the 3 immature pigs of each group were randomly sacrificed and it was found that the ovarian weight of PMtreated group was less that the control group significantly especially PM at the dosage of 25 g./ day but both dosage of PM could significantly induce the oviductal and uterine weights more than the control group. PM could significantly induce not only the layer of adipost tissue at abdominal wall but also the mammary gland development but PM had no effect on body weight gained of the immature pig. The effects of PM were depend on the dosage of PM also. After cessation of PM and follow for another 4 weeks, it was found that the teat length was still longer than the control whereas the teat di ameter was not differ from the control, although the vagina was bigger than the control but was smaller than during the PM treatment, vaginal mucus was disappear and vaginal pH was not differ from the control group. It was concluded that PM could induce the teat and vaginal development of the immature female pigs. PM could inhibit ovarian development but could induce oviductal, uterine and mamary gland development. PM could also pronounced its effect on hair and skin epidermal development whereas PM has no effect on the body weight gained of the immature female pigs. After cessation of PM; the teat length was still long but not fully developed, the vagina was still big but smaller than during PM treatment, the flaking of skin epidermis was disappear while the hair still long and shiny.

Published: N/A

Effects of Pueraria Mirifica on Vascular Function of Ovariectomized Rabbits

Authors: Suvara K Wattanapitayakul, PhD*, Linda Chularojmontri, MS**, Supatra Srichirat, PhD***
* Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University
** Inter-department of Pharmacology, Graduate School, Chulalongkorn University
*** Department of Pharmacology, Faculty of Veterinary, Chulalongkorn University

Estrogen stimulates endothelial nitric oxide (NO) production and attenuates endothelial dysfunction in ischemia/repurfusion and menopause. Recent studies have shown that phytoestrogens from dietary sources improve endothelial function and reduce cardiovascular risks. The Thai medicinal plant Pueraria mirifica (PM) contains many potent phytoestrogens including miroestrol and deoxymiroestrol but no study on vascular function has been stablished. Ground powder of PM was orally given to ovariectomized White New Zealand rabbits (OVX + PM group) (n = 4) weighing 3.2-4.0 kg at the dose of 100 mg/kg for 90 days. Saline-treated ovariectomized rabbits were assigned as a control group (OVX group) (n = 5). At the end of treatment thoracic aorta was isolated for functional evaluation. Maximal relaxant response to acetylcholine (ACh) was significantly increased (24%) with 3.5-fold decrease in EC50 while no change in relaxant response to sodium nitroprusside was observed. Minimal and maximal responses to 17ß-estradiol (E2) were increased in the OVX + PM group and L-NAME (100 mM) attenuated Emax of E2. PM significantly decreased maximal contractile responses to norepinephrine (NE), but no change in EC50 was observed. In addition to vascular study, the authors found no significant alteration in serum cholesterol, LDL, triglyceride, HDL, ALT, AST, alkaline phosphatase, and lipid peroxidation in OVX + PM rabbits. These data demonstrate that PM (100 mg/kg/d) improved endothelial function through NO-dependent pathway and increased response to E2 while sensitivity to NE was reduced. In addition, it had no impact on lipid profile, liver enzymes, and ALP activities. PM is a potential source of phytoestrogens for postmenopausal women to improve cardiovascular function or reduce cardiovascular risks.

Published: 2008
Keywords: Phytoestrogens, Pueraria mirifica, Hippocampal neuron, 17ß-estradiol, Synaptophysin, Synaptic density

Efficacy Comparison of Pueraria mirifica (PM) against Conjugated Equine Estrogen (CEE) with/without Medroxyprogesterone Acetate (MPA) in the Treatment of Climacteric Symptoms in Perimenopausal Women: Phase III Study

Authors: Verapol Chandeying MD*, Malinee Sangthawan MD**
* Faculty of Medicine, Prince of Songkhla University, Hat Yai, Songkla
** Hat Yai Regional Hospital, Hat Yai, Songkla

Objective: To evaluate the efficacy comparison of Pueraria mirifica (PM), name in Thai is Kwao Kruea Khao, against conjugated equine estrogen (CEE) with/without medroxyprogesterone acetate (MPA) in the treatment of perimenopuasal women with climacteric symptoms. Material and Method: Perimenopausal women attending the Menopausal clinic of Hat Yai Regional Hospital were voluntarily recruited. The vasomotor symptoms such as hot flushes and night sweats, as well as other unpleasant symptoms, urogenital and psychological symptoms, were also assessed. Patients were voluntarily enrolled and randomly received daily 50 mg raw material of PM, Group A, or daily 0.625 mg of conjugated equine estrogen (CEE) with/without 2.5 mg of medroxyprogesterone acetate (MPA), Group B, depend on nonhysterectomized/ hysterectomized condition.

Results: Seventy-one patients were enrolled. Eleven of those were excluded for failing to complete the initial work-up and follow-up. Sixty cases were evaluated, 30 cases in Group A and 30 cases in Group B. After medication, the mean of modified Greene climacteric scale (MGCS) in Group A/Group B had decreased from 29.0/32.26 to 17.86/18.1, 2.56/9.57 and 9.9/8.16 at 1-, 3-, and 6- month respectively. The clinical satisfaction using MGCS was not statistically significant between PM (Group A) and CEE with/without MPA (Group B) in the alleviation of climacteric symptoms (p-value > 0.05,). There were no statistically significant changes of three serum markers: estradiol, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) between both groups.

Conclusion: PM, containing phytoestrogens, has estrogenic effect as similar as CEE, and can alleviate the climacteric symptoms in perimenopausal women. PM demonstrates great promise in the treatment of climacteric symptoms. However, optimal doses should be clinically assessed to meet appropriate individual responses.

Published: 2007
Keywords: Pueraria mirifica, Conjugated equine estrogen, Medroxyprogesterone acetate, Vasomotor symptoms, Perimenopausal women, Phytoestrogen
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